Elvira Mennillo, PhD

Postdoctoral Scholar

Medicine

+1 415 502-4444

As a Specialist in the Medicine department at UCSF, my career has been focused on conducting impactful research in the field of medicine. My current studies involve detailed multi-omics analysis of intestinal tissue and peripheral blood in patients with Inflammatory Bowel Disease (IBD) as well as establishing and characterizing primary human intestinal organoids from patients.

I have authored a range of research publications that delve into various topics exploring the role of microbial signals and molecular pathways in intestinal tissue damage, the protective effects of UDP-Glucuronosyltransferase 1A1 against irinotecan-induced toxicity, and the role of nuclear receptor corepressor 1 (NCoR1) in maintaining intestinal homeostasis and protecting from ulcerative colitis.

Additionally, my work has investigated the regulation of gene expression and the impact of environmental factors on cellular responses in various organisms, including fish and avian species. Through my research efforts, I aim to contribute to the understanding of disease mechanisms and develop novel approaches for improved patient care and outcomes.

Publications:

Triclosan administration to humanized UDP-glucuronosyltransferase 1 neonatal mice induces UGT1A1 through a dependence on PPARα and ATF4.

The Journal of biological chemistry

Weber AA, Yang X, Mennillo E, Wong S, Le S, Ashley Teo JY, Chang M, Benner CW, Ding J, Jain M, Chen S, Karin M, Tukey RH

Dysregulation of CD4+ and CD8+ resident memory T, myeloid, and stromal cells in steroid-experienced, checkpoint inhibitor colitis.

Journal for immunotherapy of cancer

He JY, Kim YJ, Mennillo E, Rusu I, Bain J, Rao AA, Andersen C, Law K, Yang H, Tsui J, Shen A, Davidson B, Kushnoor D, Shi Y, Fan F, Cheung A, Zhang L, Fong L, Combes AJ, Pisco AO, Kattah MG, Oh DY

Single-cell and spatial multi-omics highlight effects of anti-integrin therapy across cellular compartments in ulcerative colitis.

Nature communications

Mennillo E, Kim YJ, Lee G, Rusu I, Patel RK, Dorman LC, Flynn E, Li S, Bain JL, Andersen C, Rao A, Tamaki S, Tsui J, Shen A, Lotstein ML, Rahim M, Naser M, Bernard-Vazquez F, Eckalbar W, Cho SJ, Beck K, El-Nachef N, Lewin S, Selvig DR, Terdiman JP, Mahadevan U, Oh DY, Fragiadakis GK, Pisco A, Combes AJ, Kattah MG

Single-cell and spatial multi-omics identify innate and stromal modules targeted by anti-integrin therapy in ulcerative colitis.

bioRxiv : the preprint server for biology

Mennillo E, Kim YJ, Rusu I, Lee G, Dorman LC, Bernard-Vazquez F, Bain JL, Patel R, Andersen C, Rao A, Tamaki S, Tsui J, Shen A, Naser M, Eckalbar W, Cho SJ, Beck K, El-Nachef N, Lewin S, Selvig DR, Terdiman JP, Mahadevan U, Oh DY, Fragiadakis GK, Pisco A, Combes AJ, Kattah MG

Effects of Early Life Oral Arsenic Exposure on Intestinal Tract Development and Lipid Homeostasis in Neonatal Mice: Implications for NAFLD Development.

Environmental health perspectives

Yang X, Weber AA, Mennillo E, Secrest P, Chang M, Wong S, Le S, Liu J, Benner CW, Karin M, Gordts PLSM, Tukey RH, Chen S

Oral arsenic administration to humanized UDP-glucuronosyltransferase (UGT) 1 neonatal mice induces UGT1A1 through a dependence on Nrf2 and PXR.

The Journal of biological chemistry

Yang X, Weber AA, Mennillo E, Paszek M, Wong S, Le S, Teo JYA, Chang M, Benner CW, Tukey RH, Chen S

Lactational delivery of Triclosan promotes non-alcoholic fatty liver disease in newborn mice.

Nature communications

Weber AA, Yang X, Mennillo E, Ding J, Watrous JD, Jain M, Chen S, Karin M, Tukey RH

Microbial signals, MyD88, and lymphotoxin drive TNF-independent intestinal epithelial tissue damage.

The Journal of clinical investigation

Rusu I, Mennillo E, Bain JL, Li Z, Sun X, Ly KM, Rosli YY, Naser M, Wang Z, Advincula R, Achacoso P, Shao L, Razani B, Klein OD, Marson A, Turnbaugh JA, Turnbaugh PJ, Malynn BA, Ma A, Kattah MG

Intestinal UGT1A1 and protection against Irinotecan-induced toxicity in a novel UGT1A1 tissue-specific humanized mouse model.

Drug metabolism and disposition: the biological fate of chemicals

Mennillo E, Yang X, Weber AA, Maruo Y, Verreault M, Barbier O, Chen S, Tukey RH

Potential of therapeutic bile acids in the treatment of neonatal Hyperbilirubinemia.

Scientific reports

van der Schoor LWE, Verkade HJ, Bertolini A, de Wit S, Mennillo E, Rettenmeier E, Weber AA, Havinga R, Valášková P, Jašprová J, Struik D, Bloks VW, Chen S, Schreuder AB, Vítek L, Tukey RH, Jonker JW